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Dec 1, - An elevated white blood cell count has many potential etiologies, Stressors capable of causing an acute leukocytosis include surgery, per L) in nonpregnant adults, is a relatively common finding with a wide differential. Jun 11, - A high white blood cell count usually indicates: An increased production of white blood cells to fight an infection. A disease of bone marrow, causing abnormally high production of white blood cells. An immune system disorder that increases white blood cell production.‎High white blood cell count · ‎When to see a doctor · ‎Acute lymphocytic leukemia.