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May 30, - I'm postmenopausal and often have vaginal dryness, which makes Even if you're using systemic hormone therapy pills or patches, your. Feb 25, - Normally, the walls of the vagina stay lubricated with a thin layer of clear fluid. The hormone estrogen helps maintain that fluid and keeps the lining of your vagina healthy, thick, and elastic. A drop in estrogen levels reduces the amount of moisture available.‎How to Treat Vaginal Dryness · ‎Vagifem · ‎Premarin · ‎Estrace.